Synthesis of Penicillin V
C17H20N2O5S
Principal investigator | John C. Sheehan |
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Publication year | 1957 |
Synthesis type | Total |
Number of steps | 5 (linear) |
References |
Part 1 of 1
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NaOAc
EtOH, H2O
RT, 10 h, 24%
"Also isolated was the C1'-epimer (30 % yield) which was equilibrated in refluxing pyridine."
NH2NH2
Dioxane , H2O
RT, 24 h, 82%
Et3N
CH2Cl2
0 °C, 22 h, 70%
HCl
CH2Cl2
0-5 °C, 30 h, 94%
DCC,
NaOH
Dioxane , H2O
RT, 33 h, 11%