Synthesis of Ervitsine

Structure of Ervitsine

C19H20N2O

Principal investigatorJoan Bosch
Publication year1997
Synthesis typeTotal
Number of steps 6 (linear)
References
Part 1 of 1
intermediate structure
NaH, TMS(CH2)2OCH2Cl
DMF, THF
0 °C to RT, 2 h, 93%
intermediate structure + intermediate structure
  1. i-PrN(Cy)Li
  2. H2CN+Me2 I-
THF
-78 to 0 °C, 8 h, 15%
intermediate structure
mCPBA
CH2Cl2
-10 °C, 2 h, 60%
intermediate structure
PhMe
Reflux, 60 min, 75%
intermediate structure
HCl
EtOH, H2O
Reflux, 2 h
intermediate structure
NaBH4
MeOH
0 °C, 60 min, 65% (2 steps)
intermediate structure