Synthesis of Alstonerine
C21H24N2O2
Principal investigator | Stephen F. Martin |
---|---|
Publication year | 2007 |
Synthesis type | Total |
Number of steps | 15 (linear) |
References |
Part 1 of 1
Et3N,
ClCO2Bn
CH2Cl2, MeOH
-20 °C to RT, 105 min, 76%
Boc2O,
DMAP
MeCN
99%
i-Pr3SiH
PhMe
80 °C, 93%
NaBH4,
TsOH
MeOH
55% (2 steps)
i-Bu2AlH
PhMe
-78 °C
Et3N,
MsCl
CH2Cl2
61% (2 steps)
Cl3CCOCl
Pyr
65 °C
Zn
AcOH
75% (2 steps)
TMSI
MeCN
78%
MeI,
NaH
THF
72%