Synthesis of Eurystatin A

C23H38N4O5
Principal investigator | J. Edward Semple |
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Publication year | 2001 |
Synthesis type | Total |
Number of steps | 9 (linear) |
References |
Part 1 of 1
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CH3CO2CHO
Et3N
0 °C to RT, 90%

N-Methylmorpholine,
ClCO2CCl3
CH2Cl2
-40 to -15 °C, 98%




Et2NH
CH2Cl2
RT, ON, 75%

Pd/C,
H2
MeOH
95%

NaHCO3,
(PhO)2P(O)N3
DMF
0-4 °C, 5 d, 85%

HCl
EtOAc
0 °C to RT, 100%


HOAt,
EDC
DMF
RT, 93%

