Synthesis of Indolizidine 223A

C15H29N
Principal investigator | Dawei Ma |
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Publication year | 2005 |
Synthesis type | Total |
Number of steps | 11 (linear) |
References |
Part 1 of 1
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LiAlH4
THF
Reflux, 12 h, 90%

SOCl2
CHCl3
0 °C to Reflux, 60 min

Pd(OH)2/C,
H2
50 atm
MeOH
40 °C, 48 h, 90% (2 steps)


K2CO3
4 Å MS
MeCN
Reflux, 80%

PtO2,
H2
1 atm
AcOH
RT, 2 h

NaOEt
EtOH
Reflux, 5 h, 81% (2 steps)

LiAlH4
THF
RT, 60 min, 91%



H2,
Pd/C
EtOAc
RT, 2 h, 49% (3 steps)
