Synthesis of Camptothecin

C20H16N2O4
Principal investigator | Henry Rapoport |
---|---|
Publication year | 1972 |
Synthesis type | Total |
Number of steps | 15 (linear) |
References |
Part 1 of 1

H2,
NH3,
Rh/Al2O3
2 atm
H2O
RT, 24 h



NaOAc
70-75 °C, 7 h, 80%


NaBH4,
NaOH
H2O, MeOH
0 °C, 20.5 h, 87%

Ac2O
2.5 h, 84%

SeO2
AcOH
100 °C, 15 min

H2SO4,
Ac2O
AcOH
140 °C, 30 min, 69% (2 steps)

K2CO3
MeOH
RT, 30 min, 100%




SeO2
AcOH
80 °C, 2.5 h


O2,
CuCl2,
Me2NH
1 atm
DMF, H2O
RT, 5 h, 99%
