Synthesis of Hirsutene

C15H24
Principal investigator | Benjamin List |
---|---|
Publication year | 2008 |
Synthesis type | Total |
Number of steps | 12 (linear) |
References |
Part 1 of 1



Mg
MeOH
0 °C, 3.5 h, 88%

KOH
EtOH, H2O
0 °C to RT, 24 h, 77%

(COCl)2
CH2Cl2, DMF
0 °C

TMSCHN2
MeCN, THF
0 °C, 4 h, 73%

(Ph3P)CpRuCl
CH2Cl2
55 °C, 30 min, 52%
"Also isolated was 22% trans isomer"

Pd/C,
H2
1 atm
EtOAc
RT, 3 h, 91%


NaOH
Et2O, H2O
RT, 24 h, 99%

- Li
- MeI
NH3, THF
-78 °C, 20 min, 75%

