Synthesis of Xyloketal A

C27H36O6
Principal investigator | Peter D. Wilson |
---|---|
Publication year | 2006 |
Synthesis type | Total |
Number of steps | 8 (linear) |
References |
Part 1 of 1
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- LDA
- Propargyl bromide
HMPA, THF
-78 °C, 20.5 h, 77%

LiAlH4
THF
0 °C, 45 min, 73%

NaNH2
Reflux, 4 h

Reflux, 18 h, 72% (2 steps)

Cl3CCOCl,
Pyr
CH2Cl2
-78 °C to RT, 21 h, 93%

NaHCO3
MeOH
Reflux, 1 h, 98%

LiAlH4
Et2O
0 °C to RT, 20 min


MgSO4,
BF3.OEt2
Et2O
-78 °C, 20 min, 63%
