Synthesis of Aspidospermidine

C19H26N2
Principal investigator | Samir Z. Zard |
---|---|
Publication year | 2006 |
Synthesis type | Total |
Number of steps | 11 (linear) |
References |
Part 1 of 1


H2,
Pd/C
MeOH
91%




ClCO2i-Bu,
Et3N
THF
0 °C, 2.5 h

BzCl,
Et3N
CH2Cl2
RT, 15 min, 67% (2 steps)

n-Bu3SnH,
ACCN
PhCF3
RT, 12 h, 53%

9-BBN
THF
Reflux, 1 h, 93%



NaBH4
MeOH
0 °C to RT, 2 h, 88%
