Synthesis of Physostigmine

C15H21N3O2
Principal investigator | Percy L. Julian |
---|---|
Publication year | 1935 |
Synthesis type | Total |
Number of steps | 10 (linear) |
References |
Part 1 of 1

- Na
- Me2SO4
- EtOH , KOH , H2O
Xylene(s)
Reflux, 38 h, 96%


PhH
Reflux, 30 min



ClCH2CN,
NaOEt
EtOH
60 °C, 3 h, 84%

H2SO4,
PtO2,
H2
1.5 atm
AcOH
RT, 91%


Na
EtOH
RT, 2 h, 80%

AlCl3
Petroleum ether
Reflux, ON, 91%

- Na
- MeNCO
Et2O, PhH
RT, 60 min, 50%
