Synthesis of Hirsutene

C15H24
Principal investigator | Lutz Fitjer |
---|---|
Publication year | 1998 |
Synthesis type | Formal |
Number of steps | 10 (linear) |
References |
Part 1 of 1

LiAlH4
Et2O
85%

TsCl
Pyr
0-5 °C, ON, 80%


Ph3P
PhMe
Reflux, 16 h, 72%


TsOH
PhH
RT, 30 min, 79%


EtAlCl2
DCE
0 °C to RT, 23 h, 50%

KOH
H2O, MeOH
Reflux, 3 d, 96%

Pb(OAc)4,
Pyr
AcOH, PhH
Reflux, 3 h, 49%

Remaining...
93% (1 step)
"See: J. Org. Chem. 1990, 55, 2725."
