Synthesis of Jamtine

C20H25NO4
Principal investigator | Nigel S. Simpkins |
---|---|
Publication year | 2003 |
Synthesis type | Total |
Number of steps | 8 (linear) |
References |
Part 1 of 1
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AcOH
Reflux


- n-BuLi
- MeO2CCN
AcOH
-78 °C to RT, 3 h, 86%
"99:01 e.r."

NaBH4
EtOH
-5 °C, 89%


(PhSe)2,
KH
THF
50 °C

Pyr,
H2O2
CH2Cl2, H2O
RT, 65% (2 steps)

Me3O+BF4-,
2,6-Di-tert-butyl-4-methylpyridine
CH2Cl2
RT

NaBH4
MeOH
0 °C, 69%
