Synthesis of Panaxytriol

C17H26O3

Principal investigator	Samuel J. Danishefsky
Publication year	2003
Synthesis type	Total
Number of steps	9 (3 parts)
References	J. Org. Chem. 2003, 68, 4519.

Part 1 of 3

CBS Reagent, 																	
																						BH3.Me2S

																	THF															

								-30 °C, 								10 min, 								75%
							
								See the Itsuno-Corey Reduction
							
								">99:01 e.r."

AgNO3, NBS

Acetone

RT, 1 h, 100%

Report an error in this part

Part 2 of 3

Imidazole, TBSCl

DMF

0 °C to RT, 6 h, 99%

AD-mix B

																	H2O, 																	t-BuOH															

								0 °C, 								42 h, 								100%
							
								See the Sharpless Asymmetric Dihydroxylation
							
								">99:01 e.r."