Synthesis of Wodeshiol
C20H18O8
Principal investigator | Elias J. Corey |
---|---|
Publication year | 1999 |
Synthesis type | Total |
Number of steps | 8 (linear) |
References |
Part 1 of 1
VinylLi
THF
-78 °C, 30 min, 97%
MnO2
CH2Cl2
0 °C, 30 min, 75%
Et3N,
Br2
CH2Cl2, Et2O
-78 to 0 °C, 16.5 h, 70%
- t-BuLi
- n-Bu3SnCl
Et2O
-78 to -40 °C, 5 h, 84%
VO(acac)2,
t-BuOOH
CH2Cl2
0 °C, 14 h, 56%
Pyr.TsOH
PhH
80 °C, 22 h, 61%