Synthesis of Cocaine

C17H21NO4
Principal investigator | Joseph J. Tufariello |
---|---|
Publication year | 1978 |
Synthesis type | Total |
Number of steps | 9 (linear) |
References |
Part 1 of 1
+



mCPBA
CH2Cl2
0 °C to RT, 2 h

Methyl acrylate
PhMe
Reflux, 20 h, 77% (2 steps)

MsCl
Pyr
0 °C to RT, 4 h, 95%

DBN
PhH
RT, 4 h, 86%


MeI
CH2Cl2, Et2O
RT, 12 h, 58%

Zn
AcOH, H2O
70 °C, 3.5 h, 47%

BzCl,
Na2CO3
PhH
Reflux, 10 h, 37%
