Synthesis of Cocaine
C17H21NO4
Principal investigator | Joseph J. Tufariello |
---|---|
Publication year | 1978 |
Synthesis type | Total |
Number of steps | 9 (linear) |
References |
Part 1 of 1
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mCPBA
CH2Cl2
0 °C to RT, 2 h
Methyl acrylate
PhMe
Reflux, 20 h, 77% (2 steps)
MsCl
Pyr
0 °C to RT, 4 h, 95%
DBN
PhH
RT, 4 h, 86%
MeI
CH2Cl2, Et2O
RT, 12 h, 58%
Zn
AcOH, H2O
70 °C, 3.5 h, 47%
BzCl,
Na2CO3
PhH
Reflux, 10 h, 37%