Synthesis of Phyllantidine

C13H15NO3
Principal investigator | Michael A. Kerr |
---|---|
Publication year | 2006 |
Synthesis type | Total |
Number of steps | 12 (linear) |
References |
Part 1 of 1
+
+
+



Yb(OTf)3
4Å MS
PhMe
RT to Reflux, ON, 86%



TMS2NK
THF
-78 °C, 2.5 h, 80 &

LiAlH4
THF
0 °C, 2 h, 97%
"The major diastereoisomer was separated via its acetonide in (52 % yield)."

IBX
DMSO
RT, 2 h, 64%


IBX
DMSO
RT, 2 h, 79%



DCC
CH2Cl2
RT, 60 min, 71%


DDQ
CH2Cl2, H2O
RT, ON, 98%

