Synthesis of Tacamonine
C19H22N2O
Principal investigator | Mauri Lounasmaa |
---|---|
Publication year | 1995 |
Synthesis type | Total |
Number of steps | 12 (linear) |
References |
Part 1 of 1
+
100 °C, 90 min, 96%
Et3N,
Pd/C,
H2
MeOH
RT, 15 h, 94%
CF3CO2H
79%
LiAlH4
THF
60 °C, 45 min, 92%
TsCl
Pyr
-20 °C, 80%
NaCN
DMF
60 °C, 95%
NaOH
H2O
POCl3
90% (2 steps)
mCPBA
NaBH4
AcOH, MeOH
50%
"Also isolated was the C20-epimer (25 % yield)."