Synthesis of Decarestrictine D

C10H16O5
Principal investigator | Ronaldo A. Pilli |
---|---|
Publication year | 1998 |
Synthesis type | Total |
Number of steps | 15 (3 parts) |
References |
Part 1 of 3

- NaH
- TBSCl
THF
0 °C, 91%




TBSCl,
Imidazole
DMF
100%

i-Bu2AlH
PhMe
-95 °C


H2SO4,
CrO3
Acetone, H2O
53% (2 steps)

Part 2 of 3

LiAlH4
THF
15 °C to reflux, ON, 85%

TBSCl
83%

Part 3 of 3
+



Pyr.HF
Pyr, THF



HF,
n-Bu4N+ F-
MeCN
80%
