Synthesis of Methoxatin

Structure of Methoxatin

C14H6N2O8

Principal investigatorElias J. Corey
Publication year1981
Synthesis typeTotal
Number of steps 9 (linear)
References
Part 1 of 1
intermediate structure
HCO2Ac
HCO2H
RT to 50 °C, 30 min, 95%
intermediate structure
H2, PtO2
EtOH
65 °C, , 93%
intermediate structure + intermediate structure
HCl, NaNO2
H2O, MeOH
0 °C, 8 h, 80%
intermediate structure
HCO2H
80 °C, 10 h, 72%
intermediate structure
HCl
Acetone, H2O
Reflux, 60 min, 79%
intermediate structure + intermediate structure
HCl
CH2Cl2
RT, 17 h, 90%
intermediate structure
(NH4)2Ce(NO3)6
H2O, MeCN
0 °C, 10 min, 60%
intermediate structure
TsOH
HC(OMe)3
Reflux, 4 h, 92%
intermediate structure
HCl, K2CO3
H2O
85 °C, 4 h, 98%
intermediate structure