Synthesis of L-163007

Structure of L-163007

C34H38F3N5O6S

Principal investigatorLinda L. Chang
Publication year1994
Synthesis typeTotal
Number of steps 10 (3 parts)
References
Part 1 of 3
intermediate structure + intermediate structure
Et3N
PhMe
50 to 95 °C, ON, 58%
intermediate structure
Part 2 of 3
intermediate structure
t-BuNH2
CHCl3
RT, 12 h, 84%
intermediate structure + intermediate structure
Pd(PPh3)2Cl2
DMF
90 °C, 5 h, 74%
See the Stille Coupling
intermediate structure
AIBN, NBS
CCl4
Reflux, 3 h, 78%
intermediate structure
Part 3 of 3
intermediate structure + intermediate structure
NaH
DMF
50 °C, 4 h, 92%
intermediate structure
ClF2CCO2Me, KF, CuI
DMF
120 °C, 12 h, 37%
intermediate structure
PtO2, H2
4 atm
EtOAc, EtOH
RT, 100%
intermediate structure
EtCOBr, DMAP
Pyr
RT, ON, 90%
intermediate structure
PhOMe
CF3CH2OH
RT, ON, 91%
intermediate structure
NaH, Boc2O
THF
50 °C, 22 h, 74%
intermediate structure