Synthesis of Pancracine

Structure of Pancracine

C16H17NO4

Principal investigator	Osamu Hoshino
Publication year	1993
Synthesis type	Formal
Number of steps	7 (linear)
References	J. Chem. Soc., Perkin Trans. 1 1993, 101.

Part 1 of 1

intermediate structure

K2CO3, (CF3CO)2O

CHCl3

RT, 30 min, 79%

intermediate structure

ZnI2, PhSH

DCE

RT, 60 min, 98%

intermediate structure

K2CO3

H2O, MeOH

Reflux, 30 min, 100%

intermediate structure

+

intermediate structure

Et4N+ I-, Et3N

MeCN

Reflux, 3 h, 56%

intermediate structure

n-Bu3SnH, AIBN

o-Xylene

Reflux, 2 h, 77%

intermediate structure

DDQ

Dioxane

Reflux, 30 min, 76%

intermediate structure

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Remaining...

53% (2 steps)

"See: J. Org. Chem. 1991, 56, 5005."

intermediate structure