Synthesis of Pancracine

Structure of Pancracine

C16H17NO4

Principal investigatorOsamu Hoshino
Publication year1993
Synthesis typeFormal
Number of steps 7 (linear)
References
Part 1 of 1
intermediate structure
K2CO3, (CF3CO)2O
CHCl3
RT, 30 min, 79%
intermediate structure
PhSH, ZnI2
DCE
RT, 60 min, 98%
intermediate structure
K2CO3
H2O, MeOH
Reflux, 30 min, 100%
intermediate structure + intermediate structure
Et3N, Et4N+ I-
MeCN
Reflux, 3 h, 56%
intermediate structure
AIBN, n-Bu3SnH
o-Xylene
Reflux, 2 h, 77%
intermediate structure
DDQ
Dioxane
Reflux, 30 min, 76%
intermediate structure
Remaining...
53% (2 steps)
"See: J. Org. Chem. 1991, 56, 5005."
intermediate structure