Synthesis of Pancracine

C16H17NO4
Principal investigator | Osamu Hoshino |
---|---|
Publication year | 1993 |
Synthesis type | Formal |
Number of steps | 7 (linear) |
References |
Part 1 of 1
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K2CO3,
(CF3CO)2O
CHCl3
RT, 30 min, 79%

ZnI2,
PhSH
DCE
RT, 60 min, 98%

K2CO3
H2O, MeOH
Reflux, 30 min, 100%


Et4N+ I-,
Et3N
MeCN
Reflux, 3 h, 56%

n-Bu3SnH,
AIBN
o-Xylene
Reflux, 2 h, 77%

DDQ
Dioxane
Reflux, 30 min, 76%

Remaining...
53% (2 steps)
"See: J. Org. Chem. 1991, 56, 5005."
