Synthesis of Thiarubrine B

C13H8S2
Principal investigator | Eric Block |
---|---|
Publication year | 1994 |
Synthesis type | Total |
Number of steps | 12 (linear) |
References |
Part 1 of 1
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- n-BuLi
- S8
- BnBr
Et2O
-78 °C to RT, ON, 100%

n-Bu4N+ F-
H2O, THF
RT, 2.5 h, 96%


Et3B,
Pd(PPh3)4,
Ph3SnH
Hexane(s), PhMe
-30 °C to RT, ON, 56%

I2
CH2Cl2
0 °C, 2 h, 97%


I2
CH2Cl2
0 °C, 2 h, 95%



n-Bu4N+ F-
THF
RT, 3 h, 86%



KOH,
I2
MeOH
-35 to 0 °C, 17% (2 steps)
