Synthesis of Hirsutene

C15H24

Principal investigator	Philip Magnus
Publication year	1985
Synthesis type	Total
Number of steps	10 (linear)
References	J. Org. Chem. 1985, 50, 1621.

Part 1 of 1

AgBF4

DCE, CH2Cl2

-50 °C to RT, 20 h, 38%

See the Nazarov Cyclization Reaction

MeLi

Et2O

-78 °C, 4 h

H2SO4, HgCl2, HgO

H2O, THF

RT, 14 h, 94% (2 steps)

t-BuLi, 																	
																						BF3.OEt2, 																	
																						CuI

																	Et2O, 																	HMPT															

								-120 to -20 °C, 								9 h, 								60%
							
								See the Michael Addition
							
								"The yield was 74 % brsm."