Synthesis of Nupharamine

C15H25NO2
Principal investigator | Franklin A. Davis |
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Publication year | 2006 |
Synthesis type | Formal |
Number of steps | 8 (linear) |
References |
Part 1 of 1
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Ti(OEt)4
CH2Cl2
RT, 5 h, 92%


CF3CO2H
MeOH
0 °C, 2 h


MgSO4
CH2Cl2
RT, 2 h, 86% (2 steps)


BF3.OEt2,
(CH2SH)2
CH2Cl2
0 °C to RT, 2 h, 93%

Ni (Raney)
EtOH
Reflux, 2 h, 78%

Remaining...
(3 steps)
"See: J. Org. Chem. 1999, 64, 3736."
