Synthesis of Nupharamine

C15H25NO2
Principal investigator | Toshio Honda |
---|---|
Publication year | 1994 |
Synthesis type | Formal |
Number of steps | 10 (linear) |
References |
Part 1 of 1
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Sm,
(CH2I)2
HMPA, THF
RT, 86%
"The starting material is obtained from (-)-carvone in 4 steps."

n-Bu4N+ F-
THF
RT

i-Bu2AlH
THF
-78 °C, 97% (2 steps)



TsOH
DMF
RT, 70% (2 steps)


n-BuLi
THF
-78 °C, 92%


Ph3P
THF
Reflux

NaBH4
EtOH
RT, 77% (2 steps)

Remaining...
37% (1 step)
"See: Collect. Czech. Chem. Commun., 1991, 56. 1309."
