Synthesis of LY311727

Structure of LY311727

C22H27N2O5P

Principal investigatorMichael J. Martinelli
Publication year1996
Synthesis typeTotal
Number of steps 8 (linear)
References
Part 1 of 1
intermediate structure + intermediate structure
MeNO2
RT, 2 d, 52%
intermediate structure
MeI, NaOH, n-Bu4N+ Br-
H2O
Reflux, 30 min, 80%
intermediate structure
LiAlH4
THF
0 °C, 4 h, 78%
intermediate structure
BF3.OEt2, TMSCN
CH2Cl2
0 °C, 60 min, 83%
intermediate structure
KOH
t-BuOH
Reflux, 60 min, 85%
intermediate structure
BBr3
CH2Cl2
0 °C, 2 h, 80%
intermediate structure + intermediate structure
K2CO3, KOH, n-Bu4N+ Br-
DMF
RT, 16 h, 89%
intermediate structure
TMSI
CH2Cl2
RT, 90 min, 92%
intermediate structure