Synthesis of LY311727

C22H27N2O5P
Principal investigator | Michael J. Martinelli |
---|---|
Publication year | 1996 |
Synthesis type | Total |
Number of steps | 8 (linear) |
References |
Part 1 of 1
+
+



MeI,
n-Bu4N+ Br-,
NaOH
H2O
Reflux, 30 min, 80%

LiAlH4
THF
0 °C, 4 h, 78%

TMSCN,
BF3.OEt2
CH2Cl2
0 °C, 60 min, 83%

KOH
t-BuOH
Reflux, 60 min, 85%

BBr3
CH2Cl2
0 °C, 2 h, 80%


n-Bu4N+ Br-,
KOH,
K2CO3
DMF
RT, 16 h, 89%

TMSI
CH2Cl2
RT, 90 min, 92%
