Synthesis of Strychnine

C21H22N2O2
Principal investigator | Christopher D. Vanderwal |
---|---|
Publication year | 2011 |
Synthesis type | Formal |
Number of steps | 9 (3 parts) |
References |
Part 1 of 3
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AllylNH2
RT, 44 h, 100%




Part 2 of 3

Me2SiH(OEt),
[Cp*Ru(MeCN)3]PF6
Acetone
0 °C to RT, 2.5 h


MeMgBr
Et2O
-78 °C, 35 min, 47% (3 steps)

Part 3 of 3
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i-Pr2NEt,
Pd(PPh3)4
CHCl3, MeCN
0 °C, 3.5 h, 69%


Remaining...
70% (1 step)
"See: Chem. Ind. 1953, 245."
