Synthesis of Strychnine

C21H22N2O2
Principal investigator | Graham J. Bodwell |
---|---|
Publication year | 2002 |
Synthesis type | Formal |
Number of steps | 9 (linear) |
References |
Part 1 of 1
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s-BuOH
Reflux, 4 d, 100%

KOH,
AllylBr
DMF
RT, 3 h, 91%


TMS2NNa,
ClCO2Me
THF
-78 °C to RT, 4 h, 96%


NaBH4
PhH, CF3CO2H
0 °C to RT, 12 h, 100%

Celite,
H2Cr2O7.2Pyr
CH2Cl2
RT, 3 d, 30%

TMSI
CHCl3
Reflux, 6 h, 100%

Remaining...
16% (4 steps)
"See : J. Org. Chem. 1994, 59, 2685; J. Org. Chem. 1993, 58, 7490."
