Synthesis of Dysibetaine
C9H16N2O4
Principal investigator | Yoshihisa Kobayashi |
---|---|
Publication year | 2009 |
Synthesis type | Total |
Number of steps | 11 (linear) |
References |
Part 1 of 1
+
Cl3CCH(OH)2
SOCl2
Reflux, 60 h
NaI,
NaN3
MeCN
RT, 90 min, 99%
Pyr,
Ac2O
CH2Cl2
RT, 24 h, 92%
Camphorsulfonic acid
PhH
60 °C, 90 min, 29%
"Also isolated was the C5-epimer (50 % yield)."
NaOH
H2O, MeOH
RT, 36 h, 100%
Pd/C,
HCl,
H2,
CH2O
1 atm
H2O, MeOH
RT, 18 h, 99%
MeI
THF
RT, 24 h, 84%
Dowex 550A
MeOH
100%