Synthesis of Cubane

C8H8
Principal investigator | Philip E. Eaton |
---|---|
Publication year | 1964 |
Synthesis type | Total |
Number of steps | 15 (linear) |
References |
Part 1 of 1


Br2
CH2Cl2, Pentane
0 to 10 °C


TsOH,
(CH2OH)2
PhH
Reflux

HCl
H2O
85% (2 steps)

hν
MeOH
95%


SOCl2

t-BuOOH,
Pyr
Et2O
95% (2 steps)

Cumene
152 °C, 55%

H2SO4
H2O
95%


SOCl2

t-BuOOH
Et2O
98% (2 steps)

Diisopropylbenzene
150 °C, 30%
