Synthesis of Colchicine
C22H25NO6
Principal investigator | Martin G. Banwell |
---|---|
Publication year | 1996 |
Synthesis type | Total |
Number of steps | 15 (linear) |
References |
Part 1 of 1
+
H2,
Pd/C
EtOAc
RT, 10 h, 96%
NaBH4
THF
RT, 90 min, 96%
Pb(OAc)4
3 Å MS
CH2Cl2
RT, 60 min, 100%
CF3CO2H
3 Å MS
PhH, THF
0 °C, 60 min, 42%
BnBr,
K2CO3
MeCN
82 °C, 4 h, 88%
Pd/C,
H2
EtOAc
RT, 9 h, 99%
Tl(NO3)3
MeOH
-20 °C, 30 min, 83%
CF3CO2H
CH2Cl2
RT, 3 h, 48%
Ac2O
Pyr
RT, 15 min, 60% (2 steps)