Synthesis of Longifolene

C15H24
Principal investigator | William S. Johnson |
---|---|
Publication year | 1975 |
Synthesis type | Total |
Number of steps | 10 (linear) |
References |
Part 1 of 1
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- MeLi
- Br2
CH2Cl2, Et2O
-78 to 0 °C


Acetone
RT, 60 min, 76% (2 steps)

LiAlH4
Et2O
0 °C, 60 min, 92%

CF3CO2H
Et2O
0 °C, 3 min, 75%

ZnBr2,
TsOH,
NaBH3CN
Et2O
RT, 2.5 h, 91%


- i-Pr2NLi
- MeI
THF
-78 °C to RT, 2 h, 84%
"The yield was 90 % brsm."

MeLi
Et2O
48 °C, 3 h

SOCl2
Pyr
0 °C, 10 min, 80% (2 steps)
