Synthesis of Ammosamide B

C12H10ClN5O2
Principal investigator | Mark Cushman |
---|---|
Publication year | 2010 |
Synthesis type | Total |
Number of steps | 9 (linear) |
References |
Part 1 of 1
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NH3
Ethylene Glycol
140 °C, 3 h, 88%

Boc2O,
DMAP
DMF
RT, 12 h, 80%

CF3CO2H
CH2Cl2
0 °C, 4 h, 90%

Pd/C,
H2
2 atm
EtOAc
RT, 12 h, 85%



NCS
DMF
60 °C, 30 min, 75%

CF3CO2H
CH2Cl2
RT, 6 h, 65%

NaH,
MeI
DMF
RT, 30 min, 70%

NH3
H2O, THF
RT, 24 h, 80%
