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Named Reactions
Protecting Groups
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Named Reactions
Protecting Groups
Methoxymethyl acetal (MOM)
Protection :
Reagents
Solvents
Temperature
Time
Yield
i-Pr2NEt
MeOCH2Cl
CH2Cl2
0 °C to RT
3 h - ON
85-98 %
info
i-Pr2NEt
,
MeOCH2Cl
CH2Cl2
0 °C to RT, ON, 98%
info
i-Pr2NEt
,
MeOCH2Cl
CH2Cl2
0 °C to RT, 3 h, 85%
MeOCH2Cl
NaH
n-Bu4N+ I-
DMF
0 °C to RT
24 - 72 h
71-91 %
info
MeOCH2Cl
,
NaH
,
n-Bu4N+ I-
DMF
0 °C to RT, 24 h, 91%
info
MeOCH2Cl
,
NaH
,
n-Bu4N+ I-
DMF
RT, 72 h, 71%
MeOCH2Cl
NaH
DMF
0 °C - RT
2 h
74-96 %
info
MeOCH2Cl
,
NaH
DMF
0 °C to RT, 2 h, 74%
info
MeOCH2Cl
,
NaH
DMF
0 °C to RT, 2 h, 96%
Deprotection :
Reagents
Solvents
Temperature
Time
Yield
HCl
H2O
MeOH
-12 °C - RT
7 h - 3 d
65-85 %
info
HCl
H2O
,
MeOH
RT, 3 d, 85%
info
HCl
MeOH
-12 to 0 °C, 7 h, 65%
HBr
CH2Cl2
0 °C
2 h
80 &
info
HBr
CH2Cl2
0 °C, 2 h, 80%
I2
MeOH
RT
2 h
66 %
info
I2
MeOH
RT, 2 h, 66%