[2-(Trimethylsilyl)ethoxy]methyl acetal (SEM)
![[2-(Trimethylsilyl)ethoxy]methyl acetal (SEM) scheme](https://synarchive.com/images/pg/scheme/Phenol_[2-(Trimethylsilyl)ethoxy]methyl_acetal.png)
Protection :
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ReagentsTimeYield
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KH 18-Crown-6 TMS(CH2)2OCH2Cl5 h84 %KH, 18-Crown-6, TMS(CH2)2OCH2ClTHFRT, 5 h, 84%
Deprotection :
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ReagentsTimeYield
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n-Bu4N+ F-12 h60 %n-Bu4N+ F-HMPA50 °C, 12 h, 60%