Acetamide (Ac)

Acetamide (Ac) scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • Ac2O
    Pyr
    RT - 100 °C
    60 min
    94-99 %
    info
    intermediate structure
    Ac2O
    Pyr
    100 °C, 60 min, 99%
    intermediate structure
    info
    intermediate structure
    Ac2O
    Pyr
    RT, 60 min, 94%
    intermediate structure
  • Ac2O
    N/A
    RT
    5 min
    82%
    info
    intermediate structure
    Ac2O
    RT, 5 min, 82%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • KOH
    H2O MeOH
    Reflux
    6 h
    93 %
    info
    intermediate structure
    KOH
    H2O, MeOH
    Reflux, 6 h, 93%
    intermediate structure
  • HCl
    MeOH
    Reflux
    6 h
    58 %
    info
    intermediate structure
    HCl
    MeOH
    Reflux, 6 h, 58%
    intermediate structure