1-Chloroethyl carbamate (ACE)

1-Chloroethyl carbamate (ACE) scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • ClCO2CH(Cl)CH3
    N/A
    135 °C
    2 d
    72%
    intermediate structure
    ClCO2CH(Cl)CH3
    135 °C, 2 d, 72%
    intermediate structure
  • ClCO2CH(Cl)CH3 Proton Sponge
    DCE
    0 °C to refl
    3.5 h
    100%
    intermediate structure
    ClCO2CH(Cl)CH3, Proton Sponge
    DCE
    0 °C to Reflux, 3.5 h, 100%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • N/A
    MeOH
    Reflux
    3 h
    100%
    intermediate structure
    MeOH
    Reflux, 3 h, 100%
    intermediate structure
    intermediate structure
    MeOH
    Reflux, 3 h, 100%
    intermediate structure