Dimethyl acetal

Dimethyl acetal scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • HC(OMe)3 TsOH
    MeOH
    RT - 50 °C
    60 min - 12 h
    91-100 %
    info
    intermediate structure
    HC(OMe)3, TsOH
    MeOH
    40 °C, 60 min, 91%
    intermediate structure
    info
    intermediate structure
    HC(OMe)3, TsOH
    MeOH
    50 °C, 4 h, 100%
    intermediate structure
    info
    intermediate structure
    HC(OMe)3, TsOH
    MeOH
    RT, 12 h, 98%
    intermediate structure
  • CTPS
    MeOH
    Reflux
    10 h
    97 %
    info
    intermediate structure
    CTPS
    MeOH
    Reflux, 10 h, 97%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • Pyr.TsOH
    Acetone H2O
    75 °C
    9 h
    96 %
    info
    intermediate structure
    Pyr.TsOH
    Acetone, H2O
    75 °C, 9 h, 96%
    intermediate structure