1,3-Dithiane

1,3-Dithiane scheme

Protection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • BF3.OEt2 HS(CH2)3SH
    CH2Cl2
    RT
    60 min
    78 %
    info
    intermediate structure
    BF3.OEt2, HS(CH2)3SH
    CH2Cl2
    RT, 60 min, 78%
    intermediate structure

Deprotection :

  • Reagents
    Solvents
    Temperature
    Time
    Yield
  • CaCO3 MeI
    H2O MeCN
    RT - 55 °C
    10 h - 4 d
    84-98 %
    info
    intermediate structure
    CaCO3, MeI
    H2O, MeCN
    55 °C, 10 h, 98%
    intermediate structure
    info
    intermediate structure
    CaCO3, MeI
    H2O, MeCN
    RT, 4 d, 84%
    intermediate structure