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Named Reactions
Protecting Groups
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Named Reactions
Protecting Groups
Trimethylsilyl ether (TMS)
Protection :
Reagents
Solvents
Temperature
Time
Yield
Pyr
TMSCl
CH2Cl2
0 °C
15 min
96 %
info
Pyr
,
TMSCl
CH2Cl2
0 °C, 15 min, 96%
Et3N
TMSOTf
CH2Cl2
-10 to -5 °C
60 min
72 %
info
Et3N
,
TMSOTf
CH2Cl2
-10 to -5 °C, 60 min, 72%
2,6-Lutidine
TMSOTf
CH2Cl2
RT
4 h
100 %
info
2,6-Lutidine
,
TMSOTf
CH2Cl2
RT, 4 h, 100%
TMSCN
CH2Cl2
RT
15 h
82 %
info
TMSCN
CH2Cl2
RT, 15 h, 82%
Deprotection :
Reagents
Solvents
Temperature
Time
Yield
HCl
H2O
THF
0 °C - RT
60 min - 6 h
89-100 %
info
HCl
H2O
,
THF
RT, 60 min, 89%
info
HCl
THF
0 °C, 6 h, 100%