Methoxymethyl acetal (MOM)
Protection :
-
-
i-Pr2NEt, MeOCH2Cl
CH2Cl2
50 °C, 4 h, 90%
i-Pr2NEt, MeOCH2Cl
CH2Cl2
RT, 18 h, 98%
i-Pr2NEt, MeOCH2Cl
CH2Cl2
RT, 18 h, 98%
-
P2O5, CH2(OMe)2
CHCl3
RT, 4 h, 86%
-
DMAP, i-Pr2NEt, MeOCH2Cl
CH2Cl2
0 °C to RT, 16 h, 97%
DMAP, i-Pr2NEt, MeOCH2Cl
CH2Cl2
0 °C to RT, 16 h, 96%
DMAP, i-Pr2NEt, MeOCH2Cl
CH2Cl2
0 °C to RT, 16 h, 71%
Deprotection :
-
-
HCl
H2O, MeOH
RT, 8 h, 93%
HCl
H2O, MeOH
RT, 3 h, 89%
-
HBr
H2O, MeCN
RT, 2 h, 95%
-
TMSBr
CH2Cl2
0 °C, 30 min, 100%