Wacker Oxidation

Mechanism of the Wacker Oxidation

Original publication	Angew. Chem.. 1959, 71, 176.
Reviews	Chem. Rev.. 2011, 111, 2981. Comp. Org. Syn.. 1991, 7, 449. Curr. Org. Chem.. 2003, 7, 369. Inorg. Chem.. 2007, 46, 1903. Synthesis. 1984, 0, 369. Tetrahedron. 2007, 63, 7505.

Sample reactions

PdCl2

DMF, H2O

RT, 3.5 h, 98%

O2, CuCl2, PdCl2

DMF, H2O

RT to 57 °C, 4.5 h, 77%