Vilsmeier-Haack Formylation

Mechanism of the Vilsmeier-Haack Formylation

Original publication	Ber. Dtsch. Chem. Ges.. 1927, 60, 119.
Reviews	Comp. Org. Syn.. 1991, 2, 777. J. Prakt. Chem.. 1996, 338, 392. Org. React.. 1997, 49, 1.

Sample reactions

POCl3

DMF

0 to 95 °C, 2.5 h, 90-96%

POCl3

DMF

-30 °C, 20 min, 89%

POCl3, DMF

DCE

-10 °C to RT, 40 min, 71%

POCl3

DMF

0 to 35 °C, 60 min, 99%

POCl3

DMF

RT, 24 h, 90%