Trost Asymmetic Allylation Alkylation

Mechanism of the Trost Asymmetic Allylation Alkylation

Original publication	J. Am. Chem. Soc.. 1973, 95, 8200.
Reviews	Angew. Chem. Int. Ed.. 2008, 47, 258. Chem. Rev.. 1996, 96, 395. Chem. Rev.. 2003, 103, 2921. Chem. Sci.. 2010, 1, 427.

Sample reactions

Pd2(dba)3.CHCl3, n-Bu4N+ Cl-

CH2Cl2

RT, 12 h, 89%

Et3N, (n3-C3H3PdCl)2

CH2Cl2

RT, 8 h, 72%

(n3-C3H3PdCl)2, Trimethylsilylphthalimide

THF

40 °C, 8.5 h