Tebbe-Petasis Olefination

Schematic representation of the Tebbe-Petasis Olefination.
Mechanism of the Tebbe-Petasis Olefination
Mechanism of the Tebbe-Petasis Olefination
Original publication
J. Am. Chem. Soc.. 1978, 100, 3611. J. Am. Chem. Soc.. 1990, 112, 6392.
Reviews
Chem. Rev.. 2000, 100, 2789. Org. React.. 1993, 43, 1. Tetrahedron. 2007, 63, 4825.
Sample reactions
info
intermediate structure
Cp2TiMe2
THF
60 °C, 24 h
intermediate structure
info
intermediate structure
AlMe3, Cp2TiCl2
PhMe
-78 to 0 °C, 6 h, 66%
intermediate structure
info
intermediate structure
Pyr, Cp2TiMe2
PhMe, THF
-50 to -35 °C, 3 h
intermediate structure