Sharpless Epoxidation

Mechanism of the Sharpless Epoxidation

Sample reactions

t-BuOOH, Ti(Oi-Pr)4, (-)-DET
4 Å MS
CH2Cl2
-20 °C, 5 h, 75%


t-BuOOH, Ti(Oi-Pr)4, (-)-DET
4 Å MS
CH2Cl2
-23 °C, 20.5 h, 90%


t-BuOOH, Ti(Oi-Pr)4, (-)-DET
CH2Cl2
-23 °C, , 92%


t-BuOOH, Ti(Oi-Pr)4, (+)-DIPT
4A MS
CH2Cl2
-20 °C, 12.5 h, 80%
"95% ee"


t-BuOOH, Ti(Oi-Pr)4, (+)-DIPT
4A MS
CH2Cl2
-30 °C to RT, 7.5 h, 98%
"91% ee"
