Robinson Annulation

Schematic representation of the Robinson Annulation.
Mechanism of the Robinson Annulation
Mechanism of the Robinson Annulation
Original publication
J. Chem. Soc.. 1935, 0, 1285.
Reviews
Synthesis. 1976, 0, 777. Tetrahedron. 1976, 32, 3.
Sample reactions
info
intermediate structure
Ethyl vinyl ketone
Et3N
0 °C to RT, 7 h
intermediate structure
info
intermediate structure intermediate structure
Et3N
MeOH
intermediate structure
info
intermediate structure intermediate structure
KOEt
EtOH, PhH
0 °C to RT, 2 h, 71%
intermediate structure