Mukaiyama Aldol Addition

Mechanism of the Mukaiyama Aldol Addition

Original publication | |
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Reviews |
Sample reactions

(CH2O)3, TiCl4
MeOH
-78 °C to RT, 16 h, 65%



i-PrOTiCl3
CH2Cl2
-78 to -40 °C, 4.5 h, 76%


TiCl2(Oi-Pr)2
CH2Cl2
-78 to 0 °C, 90 min



MgBr2.OEt2
PhMe
-15 °C, 75 min, 71%
"87 % yield based on 88 % conversion. Also isolated was the C2-epimer (16 % yield)."


CH2O, Yb(OTf)3
H2O, THF
RT, 3 d
