McMurry Reaction

Schematic representation of the McMurry Reaction.

Mechanism of the McMurry Reaction

Mechanism of the McMurry Reaction

Original publication	J. Am. Chem. Soc.. 1974, 96, 4708.
Reviews	Angew. Chem. Int. Ed.. 1996, 35, 2442. Chem. Rev.. 1989, 89, 1513. Comp. Org. Syn.. 1991, 3, 563.

Sample reactions

intermediate structure

intermediate structure

TiCl3, K

THF

Reflux, 25 h, 55%

intermediate structure

intermediate structure

intermediate structure

LiAlH4, TiCl3

CH2Cl2, DME

RT to Reflux, 4.5 h, 35%

intermediate structure

intermediate structure

TiCl3, C8K

DME

RT to reflux, 20 h, 86%

intermediate structure