Maitland-Japp Reaction

Schematic representation of the Maitland-Japp Reaction.
Mechanism of the Maitland-Japp Reaction
Mechanism of the Maitland-Japp Reaction
Original publication
J. Chem. Soc., Trans.. 1904, 85, 1473.
Review
Eur. J. Org. Chem.. 2006, 0, 2045.
Sample reactions
info
intermediate structure intermediate structure intermediate structure
Yb(OTf)3
CF3CO2H
-78 °C to RT, 5 h, 60%
"Also isolated was the C2-epimer (32 % yield)."
intermediate structure